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Fırat Tıp Dergisi
2016, Cilt 21, Sayı 3, Sayfa(lar) 159-161
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Pregnancy with Cabergoline Treatment in a Woman with Bromocriptine Resistant Macroprolactinoma: Case Report
Müge ÖZSAN1, Esra KARAKAŞ1, Abdülrahim EREN2, Gülen BURAKGAZİ3, İhsan ÜSTÜN1, Cumali GÖKÇE1
1Mustafa Kemal Üniversitesi, Endokrinoloji ve Metabolizma Hastalıkları, Hatay, Türkiye
2Mustafa Kemal Üniversitesi, İç Hastalıkları, Hatay, Türkiye
3Mustafa Kemal Üniversitesi, Radyoloji, Hatay, Türkiye

Bromocriptine and cabergoline are the most preferred dopamine agonists in the therapy of prolactinomas. Primary resistance to dopamine agonists is usually seen in 10-15 % of the patients. Here, we described a case of a 19 year-old woman who was presented with amenorrhea and headache and then was diagnosed with macroprolactinoma. She was initially treated with cabergoline with a perfect response. We had switched cabergoline to bromocriptine because of the desire for pregnancy. After one year of 15 mg/day of bromocriptine treatment, the patient reported irregular menses with elevated prolactin levels. There with we changed bromocriptine to cabergoline because the cabergoline response was perfect at the beginning. We would like to emphasize that the resistance to bromocriptine therapy is not uncommon and may complicate the follow up of the patients with prolactinomas and in case of resistance, it is important to keep in mind to switch agents.

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