Hypercalcemia, mostly caused by primary hyperparathyroidism and malignancy, is a life-threating electrolyte disorder. An initial etiological work-up should include measurement of intact parathyroid hormone because of its lodestar role in patients with hypercalcemia. Parathyroid carcinoma is a rarely seen disease but can lead to severe form of hyperparathyroidism. Hypercalcemia and hyperparathyroidism scarcely cause acute pancreatitis. In this study, we report a case of a 55-year old patient admitted to our clinic with acute renal failure and hypercalcemia who developed acute pancreatitis and diagnosed with parathyroid carcinoma.