Objective: The aim of the present study was to evaluate the histopathological diagnoses and their incidences in the appendectomies performed for acute abdomen symptoms in Yozgat region.

Material and Method: 263 appendectomy specimens that were evaluated between January 2012 and October 2016 at the Pathology Department of Bozok University School of Medicine, a recently founded university, were investigated retrospectively.

Results: There were 134 (51%) males and 129 (49%) females. The age ranged from 4 to 88 years (mean =29.4±15.03 year). Among 263 cases, acute appendicitis was detected in 167 (63.4%) cases and perappendicitis was detected in 4 (1.5%) cases. Additionally, there were 73 (27.8%) cases of lymphoid hyperplasia, 7 (2.8%) cases of enterobius vermicularis, 5 (1.9%) cases of fibrous obliteration, 3 (1.1%) cases of non-necrotizing granulomatous inflammation, 2 (0.8%) cases of low-grade appendicial mucinous neoplasm, 1 (0.4%) case of leukocytoclastic vasculitis, and 1 (0.4%) case of carcinoid tumor.

Conclusion: A variety of incidental pathologies particularly benign/malignant tumors, and parasitic infections that require additional treatment might be detected in the appendectomy specimens performed for a clinical diagnosis of acute appendicitis. Thus, histopathological examination is crucial and has to be done carefully.