[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]
Fırat Tıp Dergisi
[ Turkish ] [ PDF ]
Are Fibrocystic Changes Innocent? Importance of HER-2 in Fibrocystic Changes of Breast and Correlation Breast Cancer Risk
Özgen ARSLAN SOLMAZ
Elazığ Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, Elazığ, Türkiye

Objective: Fibrocystic change refers to nonproliferative lesion. Determining whether this lesion is a risk factor for developing breast cancer has been one of the most important issues. In order to determine this risk, we used HER-2 by immunohistochemistry in this study.

Material and Method: 163 mastectomy materials which had tumor diagnosis between 1995 and 2016 in our clinic and had findings of fibrocystic changes in non-tumor areas, and 151 excisional breast biopsy materials which had diagnosis of fibrocystic change but had not malignant mass were included into the study. The tissues containing fibrocystic changes in both groups were stained with HER-2 by immunohistochemical methods.

Results: It was found that HER-2 staining was more frequent in FCC areas with in mastectomy cases due to tumor (χ2 = 37,079; p =,000).

Conclusions: We found out that HER 2 staining was significantly more positive in fibrocystic change cases with in mastectomy cases due to tumor than non-malignant cases and that the risk of malignancy was higher in HER-2 positive cases. We believe that HER-2 staining for breast biopsies will be helpful for determining malignancy potential in benign lesions of breast.


[ Turkish ] [ PDF ]
[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]