Fırat Tıp Dergisi |
2018, Cilt 23, Sayı 3, Sayfa(lar) 022-029 |
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Relation between Obesity and the Gastrointestinal System |
Abdurrahman ŞAHİN, Mehmet YALNIZ |
Fırat Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gastroenteroloji Bilim Dalı, Elazığ, Türkiye |
The obesity epidemic is rapidly becoming one of the leading causes of mortality and morbidity worldwide. Over the past 30 years, gastrointestinal hormones have been increasingly understood to have an important role as regulators of appetite and energy balance in obese individuals. Intestinal microbiota also plays a significant role in the development of obesity, obesity-associated inflammation and metabolic syndrome. In this review we discuss the effects of enteric hormones and intestinal microbiota on the pathophysiological mechanisms revealing obesity, including ingestive beha-vior, energy expenditure and metabolism.
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[ Turkish ]
[ PDF ]
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