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Fırat Tıp Dergisi
2019, Cilt 24, Sayı 1, Sayfa(lar) 006-013
[ Turkish ] [ Tam Metin ] [ PDF ]
The Role of Duodenogastric Reflux in Development of Gastric Cancer: An Experimental Research of the Preventive Effects of Cyclooxygenase-2 Inhibitors and Honey
Sebahattin DESTEK1, Vahit Onur GÜL2, Yersu KAPRAN3, Emre BALIK4, Dursun BUĞRA4, Ali AKYÜZ4
1Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye
2Edremit Devlet Hastanesi, Genel Cerrahi Kliniği, Balıkesir, Türkiye
3İstanbul Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye
4İstanbul Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye

Objective: The aim of this experimental study was to evaluate the preventive effects of cyclooxgenase-2 (COX-2) inhibitors and polifloral honey on the gastric carcinogenesis in a duodenogastric reflux model.

Material and Method: Thirty-six rats were enrolled in the study and simple gastrojejunostomy was performed in all the animals. The rats were separated in three equal groups with 12 animals each. In the first group (control) only standard rat food and tap water were given. Additionnally, 5mg/kg/day meloxicam and 5 ml/kg/day polifloral honey were given in the second (COX-2) and third (honey) groups respectively. Forty weeks after the operation, all rats were sacrified with high dose diethyl ether inhalation. The mucosa of the anastomotic region and stomach was evaluated in light microscope with hematoxylene-eosin, and also immunohistochemistry was done with p53 and COX-2 antibodies.

Results: In control and COX-2 groups gastric adenocarcinoma was found in 3 (30%) and 2 (22%) animals respectively. In the polifloral honey group no adenocarcinoma was revealed. Despite these findings, a statistically significant difference was not found between the groups due to a small sample size.

Conclusion: The exocrine pancreatic secretion and bile induces a carcinogenic effect on the gastric mucosa in an experimental duodenogastric reflux model. In the present study we can conclude that the protective effect of polifloral honey is much more pronounced than the effect of COX-2 inhibitors.


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