Double pylorus is a rare abnormality characterized by formation of a short accessory canal between antrum and duodenal bulb. It has been reported in 0.06-0.4% and often discovered incidentally at endoscopy. It can be asymptomatic or present with upper abdominal pain, dyspepsia and gastrointestinal bleeding. Fiftyfive-years-old male patient admitted to our clinic with dyspeptic complaints and upper abdominal pain. The past medical history of the patient included an operation, chemotherapy, radiotherapy due to rectum cancer. An endoscopy revealed two lumens located in prepyloric antrum. Endoscopy could pass through one lumen but could not go thorough the other smaller lumen. Since we cannot go through one of the lumens, barium stomach duodenography of the patient was taken. Barium stomach duodenography of the patient was nondiagnostic. The final endoscopic diagnosis was double pylorus. Here, we report a first case of double pylorus with rectal cancer.