Objective: Rheumatoid arthritis is the most common systemic autoimmune, rheumatic disease that causes arthritis in the joints. The aim of this study is to compare the demographic data, clinical features and medical therapies of patients diagnosed with rheumatoid arthritis over the age of fifty and those diagnosed with rheumatoid arthritis under the age of fifty.

Material and Method: The study included 188 patients who met the 2010 ACR/EULAR rheumatoid arthritis criteria between November 2015 and July 2018. The patients were asked about the age and weight loss at the diagnosis, diabetes, hypertension, atherosclerosis, smoking and alcohol use. Patients\' joint involvement, rheumatoid factor (RF), cyclic citrulinated peptide (CCP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) values at the time of diagnosis were examined and compared with the past and now used treatments.

Results: In our study, male/female rates were found to be 3.76/1 in earlyonset and 1.8/1 in late-onset. In GBRA patients, comorbid conditions (diabetes, hypertension and atherosclerosis) were found to be statistically significantly higher, than diabetes, hypertension and atherosclerosis. According to EBRA, the mean ESR and CRP values were significantly higher in GBRA patients. Shoulder involvement was higher in patients with GBRA than in EBRA. No significant difference was found in the current treatment of GBRA and EBRA patients. Sulphasalazine (SSZ) and methotrexate (MTX) treatment were found to be more preferable in early onset in GBRA patients compared to previous medications.

Conclusion: GBRA patients were found to have a lower rate of female/male ratio than EBRA, more comorbid disease, more shoulder involvement and higher acute phase reactants at baseline.