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Fırat Tıp Dergisi
2021, Cilt 26, Sayı 2, Sayfa(lar) 083-089
[ Turkish ] [ Tam Metin ] [ PDF ]
Corelation Between Liver Fibrozis and MPV in Patients with Chronic Hepatitis B and Chronic Hepatitis C
Mehmet Nur KAYA1, Ayla YILDIZ2
1Mustafa Kemal Üniversitesi Tıp Fakültesi Hastanesi, Hematoloji Bilim Dalı, Hatay, Türkiye
2Aydın Devlet Hastanesi, Gastroentereloji Kliniği, Aydın, Türkiye

Objective: Mean platelet volume (MPV) is one of the most important parameters of platelet size and is a potential marker of platelet reactivity. Clinical and histopathological correlations with MPV have been demonstrated in most diseases. In this study, we aimed to investigate the relationship between hepatic histopathology and platelet count and MPV levels associated with viral hepatitis.

Material and Method: In our clinic, we conducted a retrospective case control study based on some histological and clinical parameters of patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The patients were divided into two groups, CHB and CHC. These groups were then divided into groups consisting of histological activity index (HAI) and fibrosis scores according to liver biopsy results. Clinical features of chronic viral hepatitis patients including demographic, laboratory and liver biopsy findings were evaluated.Results: In the study, a statistically significant difference was found between the HAI classes in patients with CHB and CHC in terms of MPV and platelet distribution width (PDW)/MPV levels (p <0.001). A statistically significant difference was found between the fibrosis classes in patients with CHB in terms of MPV and PDW/MPV levels (p <0.001). A statistically significant difference was found between the fibrosis classes in patients with CHC in terms of MPV and creatine levels (respectively p =0,032, p =0,042).

Conclusion: It can be used as a predictive parameter in patients with MPV, CHB and CHC, which are viewed by a simple method such as complete blood count. Therefore, the examination of the correlation between MPV levels and CHB and CHC with larger prospective studies is necessary to confirm these findings.


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