Ozone (O₃) can be translated from the Greek as “smelly”. The gas form was discovered in 1839 and its first medical use dates back to the First World War. Medical O₃ treatment was discussed in the “Traditional and Complementary Medicine (GETAT) Practices Regulation” published in the Official Gazette in 2014 by the Ministry of Health in our country; indications, contraindications and routes of administration are reported in this regulation. O₃ therapy; according to the current regulation, it should be done by medical doctors, in appropriate therapeutic dose and with appropriate methods.

Many studies have been conducted to investigate the primary or complementary therapy efficacy of O₃, and these studies continue to be conducted in more detail today. According to studies, although O₃ treatment may cause negative results in healthy tissues without oxidative stress, its use either alone or in combination with other therapeutic agents in cases of oxidative stress has an antioxidant effect and corrects the damage. These results give us; it shows that the complementary therapy feature of O₃ is at an effective level; but; it shows the need for more helthy tissue studies on O₃ and more studies applied as a primary treatment protocol.