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Fırat Tıp Dergisi
2022, Cilt 27, Sayı 2, Sayfa(lar) 076-081
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Nitric Oxide Serum Levels in Schizophrenia Subtypes and it’s Relationship with Clinical Variables
Özlem GÜL1, Murad ATMACA2
1T.C. Sağlık Bakanlığı İstanbul Bakırköy Prof. Dr. Mazhar Osman Ruh Sağlığı ve Sinir Hastalıkları Eğitim ve Araştırma Hastanesi, Ruh Sağlığı ve Hastalıkları Kliniği, İstanbul, Türkiye
2Fırat Üniversitesi Tıp Fakültesi, Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Elazığ, Türkiye

Objective: In the present study, serum nitric oxid (NO) levels and its relationship with clinical variables in schizophrenia subtypes were evaluated.

Material and Method: The study group was composed of 21 paranoid type, 20 disorganized type, 19 undifferentiated type and 16 residuel type schizophrenic patients who applied to Firat University School of Medicine Department of Psychiatry and 25 healthy control subjects. The patients were administered sociodemographical and clinical data form and Brief Psyhiatric Rating Scale (BPRS). Blood samples were obtained from the patients and controls between 08.00-11.00 hours. Afterwards, serum NO were determined with Griess reaction.

Results: The comparison of schizophrenic patients and healthy controls has shown that serum levels of NO in schizophrenic patients are higher than in healthy ones (p <0.001). In all subtypes of schizophrenia, serum NO levels have been found higher than in controls. In this study, no significant correlation was found between serum NO levels and sex, age, education level, smoking history or attack issues (p >0.05).

Conclusion: Our findings suggest that NO may have an important role for explaining the ethiopathophysiology of schizophrenia. In addition, due to the usage of NO as a confidential parameter for clinical characteristics, classification and prognosis in schizophrenia, it is needed to determine further studies in future.


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