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Fırat Tıp Dergisi |
2022, Cilt 27, Sayı 2, Sayfa(lar) 097-103 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
The Value of Mage–A11 at the Differantion of Invasive Carcinoma of No Special Type and Invasive Lobular Carcinomas From Benign Breast Tissues |
Ahmet KILIÇARSLAN1, Gökhan VARLI2, Gülhan KILIÇARSLAN1, Mehmet Mustafa AKIN3 |
1Elazığ Fethi Sekin Şehir Hastanesi, Patoloji Kliniği, Elazığ, Türkiye 2Karaman Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, Karaman, Türkiye 3Fırat Üniversitesi Tıp Fakültesi, Patoloji Kliniği, Elazığ, Türkiye |
Objective: Breast cancer is the second most common cancer after lung cancer and is about 26% of all cancers in women. Mortality rate is 18%.
Imaging methods, aspiration cytologies and core biopsies are useful before radical surgeries are performed. Breast carcinomas have different histopathologic
features. The reason for these different histopathologic features are the increased number of investigations on the genetic characteristics of the
tumor, and research the gene expression patterns in tumors. The melanoma-associated antigen (MAGE) family consists of a number of antigens
recognized by cytotoxic T lymphocytes. MAGE–A11 is expressed in tumors such as melanoma, breast and lung cancer. In this study we investigated
MAGE–A11 expression in invasive carcinoma of no special type, invasive lobular carcinomas and benign breast tissues.
Material and Method: A total of 150 cases as 50 benıgn breast tissue, 50 invasive carcinoma of no special type and 50 invasive lobular carcinoma were randomisely selected from Fırat University Medical Faculty Pathology Department. MAGE–A11 was applied to the samples immunohistochemically. Results: MAGE–A11 expression was observed at 33 of 50 benign breast tissues (66%), 45 of 50 invasive carcinoma of no special type ( 90%) and 35 of 50 invasive lobular (70%) carcinomas. Conclusion: MAGE–A11 cannot help in distinguishing between benign and malign breast tissues. However, it was concluded that high expression of MAGE–A11 in the no special type of invasive carcinoma can be useful in differential diagnosis with invasive lobular carcinomas. |
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