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Fırat Tıp Dergisi
2022, Cilt 27, Sayı 2, Sayfa(lar) 121-125
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Investigation of Tp-e interval, Tp-e/QT, Tp-e/QTc Ratio and Fragmented QRS Parameters in Manic Phase of Bipolar Disorder
Sevler YILDIZ1, Aslı KAZĞAN2, Denizhan DANACI KELEŞ3, Fikret KELEŞ4, Osman KURT5
1Erzincan Binali Yıldırım Üniversitesi Tıp Fakültesi Psikiyatri Ana Bilim Dalı, Erzincan, Türkiye
2Siverek Devlet Hastanesi Psikiyatri Kliniği, Şanlıurfa, Türkiye
3Elazığ Ruh Sağlığı ve Hastalıkları Hastanesi Psikiyatri Kliniği, Elazığ, Türkiye
4Elazığ Fethi Sekin Şehir Hastanesi Kardiyoloji Kliniği, Kardiyoloji, Elazığ, Türkiye
5Fırat Üniversitesi Tıp Fakültesi Halk Sağlığı Anabilim Dalı, Elazığ, Türkiye

Objective: In this study, we aimed to examine the Tp-e interval, Tp-e / QT, Tp-e / QTc ratio and fragmented qrs parameters during the manic episode period.

Material and Method: Fifty patients diagnosed with bipolar disorder manic episode for the first time and 50 healthy controls were included in the study. Sociodemographic data form and Young Mania Rating Scale (YMRS) were applied to both the patient and control groups. In addition, standard 12-lead body surface electrocardiography was performed in both groups.

Results: Tp-e interval, Tp-e / QT ratio and Tp-e / QTc ratio of the patient group were found to be higher than the control group (p <0.001). A significant correlation was found between the severity of mania symptoms and the Tp-e interval and the Tp-e / QTc ratio. In addition, the incidence of fragmented QRS in the patient group was found to be higher than the incidence of fragmented QRS in the control group (p <0.001).

Conclusion: These findings show that there is ventricular repolarization and changes in myocardial tissue in patients during manic episodes. We think that detecting cardiac problems at an early stage will decrease mortality and morbidity in this patient group.


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