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Fırat Tıp Dergisi
2005, Cilt 10, Sayı 3, Sayfa(lar) 108-112
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Effects of Melatonin and Vitamin C on Smoke Induced Structural Changes in Liver
Neriman ÇOLAKOĞLU1, Enver OZAN1 , Mehmet Fatih SÖNMEZ1, Seval YILMAZ2, Gonca OZAN3
1 Fırat Üniversitesi Tıp Fakültesi Histoloji-Embriyoloji Anabilim Dalı, ELAZIĞ
2Fırat Üniversitesi Veteriner Fakültesi, Biyokimya Anabilim Dalı, ELAZIĞ
3Fırat Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, ELAZIĞ

Objectives: This study was undertaken to investigate smoke-induced structural and biochemical changes and protective effects of co-administred of melatonin and vitamin C in the liver.

Materials and Methods: Twenty-four Wistar adult female rats were used in this study. Animals were divided into four groups. The first group rats used as control. The second group of rats were inhaleted cigarette. Cigarette inhaleted third and fourth group rats recieved melatonin and vitamin C respectively. End of experimental study liver tissues and blood samples were taken under the ether anesthesia. Tissues were prepared and examined by light microscopy. And biochemicaly, malondialdehyde and glutatyon levels and catalase activity were determined.

Results: In the light microscopic observation, sinusoidal dilatation and congestion, mononuclear cell infiltration in some area and karyorectic hepatocytes were detected in the groupe II. In the cigarette inhaleted third and fourth group rats recieved melatonin and vitamin C respectively liver tissues were protected againest smoke relatively. Biochemical examination showed us malondialdehyde and glutatyon levels and catalase activity in the group II higher than group I. While malaondialdehyde levels were decreased by melatonin and vitamin C glutatyon levels were increased. Catalase activity did not change in these groups.

Conclusion: As a result, it was determined that cigarette inhalation increased lipid peroxidation and antioxidant system and caused structural changes in the liver. However, it was determined that administration of melatonin and vitamin C provided relative protection against smoke intoxication. ©2005, Fırat Üniversitesi, Tıp Fakültesi


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