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Fırat Tıp Dergisi
2006, Cilt 11, Sayı 1, Sayfa(lar) 048-050
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Relationship between the intensity of helicobakter pylori and number of mast cells in cases of the antral gastritis
Adile Ferda DAĞLI1, Gülçin CİHANGİROĞLU1, Bengü ÇOBANOĞLU1, İbrahim H. ÖZERCAN1, İbrahim H. BAHÇECİOĞLU2, M. Reşat ÖZERCAN1
1Fırat Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, ELAZIĞ
2Fırat Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı, ELAZIĞ

Objectives: Helicobacter pylori (HP) has an important role in various gastroduodenal diseases, especially in active and chronic gastritis and mast cells is known as primary trigger of inflammation. Due to that, the relationship between the degree of HP positivity and negativity with the intensity of mast cell in the cases of antral gastritis was invested.

Materials and Methods: 160 cases that were reported as antral gastritis by Fırat Ünivercity Medicine Faculty Pathology Laboratory but not diagnosed as duodenal ulcer via endoscopic examination previously, were included in this study. The study group was divided in to 4 subgroup as HP(-), HP 1+, HP 2+ and HP 3+ and each group has 40 cases. In this study, the count of mast cell in these subgroups was compared.

Results: Mast cell count in antral gastritis in HP(-), HP 1+, HP 2+, HP 3+ cases was found (63,92±10,02, 86,27±11,08, 92,75±13,59, 121±17,73) respectively. The difference between HP(-) with HP 1+ cases and HP 2+ with HP 3+ cases about mast cell count was significant (p<0,001). But the difference between HP 1+ and HP 2+ cases wasn't significant (p>0,05).

Conclusion: Mast cell intensity that plays important role in inflammatory process, increase with HP positivity significantly. Between HP(-) and HP(+) cases there was expressive difference and degree of HP positivity and number of mast cells there was an evident increase. Our study shows that there is a relationship between degree of HP positivity and count of mast cell in antral gastritis. ©2006, Fırat Üniversitesi, Tıp Fakültesi


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