Objectives: The recent multitask studies made in the intensive care unites, it is detected that blood glucose level is one of the most determining factors for mortality. In this study the blood glucose level in experimental of sepsis in rats is altered and the effect of blood glucose level alterations on mortality is studied.

Material and Methods: 60 wistard rats are included into the study. An artificial sepsis model is designed in all subjects by matching an intraperitoneal injection of 5 mg/kg E.Coli LPS in order to determine the bacterial translocation. The subjects are divided into two groups which include the group coith blood glucose level between 85-110 and the diabetic group with blood glucose level between 180-215. Tissue samples (mesenteric lymph node, liver, spleen) are taken from the subjects which died after shocoing symptoms of shock. Bacterial translocation is studied by using PCR and blood culture methods.

Results: All the subjects in the diabetic group died in the first five day and all the subjects in the control group died in the first twelve days after LPS application. The mortality rate in the diabetic group is detected as statistically significant higher than the mortality rate in the control group (p<0.05)

Conculation: In this study mortality of experimental sepsis in rats with only alterations in blood glucose level is studied. We come to the conclusion that mortality rate is decreasing experimental sepsis in rats by keeping the blood glucose level between 80-110 mg/dl. ©2007, Firat University, Medical Faculty