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Fırat Tıp Dergisi
2007, Cilt 12, Sayı 1, Sayfa(lar) 037-040
[ Turkish ] [ Tam Metin ] [ PDF ]
Relationship Between 24-Hour Urine and Serum Parameters in Patients with Nephrolithiasis
Hüsamettin ERDAMAR, Banu SANCAK, Neslihan BUKAN, Hatice PAŞAOĞLU
Gazi Üniversitesi Tıp Fakültesi Tıbbi Biyokimya Anabilim Dalı, ANKARA

Objective: Nephrolithiasis is a common disease, whereas the mechanisms by which stones develop in the kidney are poorly understood. While high levels of oxalate, uric acid, calcium, and phosphate in the urine increase the formation of nephrolithiasis, increased urinary excretion of citrate, magnesium, albumin and alkali urine decrease this process. In this study, we aimed to identify the possible relationship between some serum and 24- hour urinary parameters in patients with nephrolithiasis.

Materials and Methods: Two hundreds thirty-one patients with nephrolithiasis (aged 18-65 years; 143 men, 88 women) were retrospectively examined in this study.

Results: Significant correlations observed between urine and serum levels of creatinine with urine and serum levels of uric acid [r= 0.70, (p<0.01) for urine; r= 0.55, (p<0.01) for serum]; urine levels of phosphorus with urine levels of urea (r= 0.998, p<0.01); urine levels of uric acid with urine levels of calcium (r= 0.488, p<0.001) and between urine levels of chlorine and uric acid (r= 0.547, p=0.00) and creatinine (r= 0.59, p<0.001).

Conclusion: In conclusion, there are some correlations between the values of urine and serum parameters. In patients with nephrolithiasis, 24-hour urine analysis may be helpful for the assessment of stone formation and development. Furthermore these correlations may conduct clinicians determine better treatment strategies. ©2007, Firat University, Medical Faculty


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