Erythema dyschromicum perstans (EDP) is a chronic, pigmentary disorder with symetrically distributed ashy macules on the face and neck, thrunk and proximal extremities. Early gray-blue macules with active red borders later become as gray-blue macules with indefinite edges. The etiology of EDP remains unclear, and it is proposed to be a reactive process to enviromental toxins or a manifestation of pigmentary allergic contact dermatitis. Therapy regimens such as sun protection, peeling lotions, antibiotics, topical and systemic corticosteroids, and vitamins have been reported to be ineffective whereas dapson therapy yielded hopefull results in various case reports. However, in our out-patient clinic, 38 and 53 years old, two female patients with EDP were treated with dapsone without any beneficial clinical outcome. Placebo-controlled clinical trials are needed to reveal out the effects of dapson on the early and late phases of EDP. ©2007, Firat University, Medical Faculty