Wilson’s disease is a metabolic storage disease resulting from the malfunction in the copper metabolism showing autosomal recessive progress. The symptoms of the disease become apparent with the buildup of toxic copper residues in the liver, brain, cornea, kidney and other tissues. The diagnosis of the Wilson’s disease should be taken into account in the patients showing neurological and physiological symptoms between the ages of 5 and 40. The most widely viewed abnormalities in T2 dominant images of MRI are the increased intensities in lenticular, thalamic, nucleus caudatus and the white matter. The signal intensities may disappear in the basal ganglia after the treatment. It is important to know the pre-diagnosis, treatment and radiological screenings of the disease. Because, if the disorder is detected early and treated correctly, the irreversible tissue damage can partly be prevented, thus the prognosis is positively affected. We report a case where cranial MRI shows signal intensities of Wilson disease, to discuss the characterization of MRI imaging at diagnosis and after treatment. ©2007, Firat University, Medical Faculty