Objectives: To present our experiences in management of thyroglossal duct cysts over 10 years and to discuss the diagnosis and treatment of thyroglossal duct cysts related with literature.

Materials and Methods: A retrospective review of charts belonged to 32 patients performed excision of thyroglossal duct cysts in our clinic.

Results: 12 of the 32 patients were male and 20 were female. The age at presentation ranged from 2 to 56 years (average age 17.9±16.1 years). The most common complaint was intermittent secretion at the middle region of the neck (53%). Rarely, a nodule or fistula point was being at the middle of the neck in patients. Fistula point or nodule was settled at the midline of the neck and thyrohyoid zone in 16 patients. Clinic presentation was a fistula in 17 patients and a cyst in 15 patients. Sistrunk operation was performed for all our patients.

Conclusion: Common opinion accepted about the treatment of thyroglossal duct cysts is surgical approach. It should be remembered that the thyroglossal duct cysts have risk of malign transformation. Physicians must keep in mind the thyroglossal duct cysts in the differantial diagnosis of the patients presented with fistula or nodule at middle of the neck and the sistrunk operation is a gold standart for the treatment of this patients. ©2007, Fırat Üniversity, Medical Faculty