Giant cell tumors can exhibit malignant behaviour and metastasize in 1% to 9% of patients. Patients with lung metastases from giant cell tumors are treated by surgical resection with very good survival rates. Chemotherapy and radiotherapy have been reserved primarily for patients with unresectable and symptomatic lung metastases. From the authors’ literature search, no patients were treated with whole-lung radiotherapy and combined chemotherapy without surgical resection. In this report, we present 8.5 years follow up of a patient with giant cell tumor of bone with pulmonary metastases treated by combination of chemotherapy with whole-lung radiotherapy without surgical resection for lung metastases. ©2007, Fırat University, Medical Faculty