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Fırat Tıp Dergisi
2008, Cilt 13, Sayı 1, Sayfa(lar) 001-004
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Testicular SOD, GSH-Px and MDA Levels in Experimental Toxicity of Formaldehyde and Protective Effect of ω-3 Fatty Acids
İlter KUŞ1, İsmail ZARARSIZ1, Murat ÖGETÜRK1, H. Ramazan YILMAZ2, Mustafa SARSILMAZ1
1Fırat Üniversitesi Tıp Fakültesi Anatomi Anabilim Dalı, ELAZIĞ
2Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik Anabilim Dalı, ISPARTA

Objective: In this study, it was aimed to investigate the effects of formaldehyde toxicity on the testes at biochemical level. Potential antioxidant effects of ω-3 fatty acids against these toxic effects were also evaluated.

Materials and Methods: In our study, a total of 21 adult male Wistar rats were divided into three equal groups. Rats in group I were used as control. Rats in group II were injected intraperitoneally with formaldehyde every other day while the other ones received ω-3 fatty acids daily via intragastric gavage (Marincap capsule®) with injections of formaldehyde. At the end of 14-days experimental period, all animals were killed by decapitation and their testes were removed. Afterwards, the activites of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the level of malondialdehyde (MDA) in testicular tissue specimens were determined spectrophotometrically.

Results: Biochemical values of group-treated formaldehyde alone showed that the enzymatic activities of testicular SOD and GSH-Px were significantly decreased compared to control values, while testicular MDA levels were significantly increased. On the other hand, it was found that there were increases in SOD and GSH-Px enzyme activities, and decreases in MDA levels in testis specimens of rats administered ω-3 fatty acids with exposure of formaldehyde.

Conclusions: In this study performed on rats, it was determined biochemically that oxidative tissue damage in testes resulting from experimental toxicity of formaldehyde was prevented by omega-3 fatty acids.. ©2008, , Firat University, Medical Faculty

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