The mortality and morbidity of stent thrombosis are very high. Although subacute stent trombosis of drug eluting stents are similar to bare metal stents, late thrombosis are higher due to delayed endothelization. There is no consensus about the treatment of stent thrombosis and different modalities like balloon angioplasty, urgent by-pass surgery, thrombolytic therapy and half dose thrombolytic therapy plus GPIIb/IIIa receptor blockers infusion all of them have advantages and pitfalls. In this case report a 55 years old male patient who had stent thrombosis due to premature discontinuation of the anti-platelet drugs were treated by half dose thrombolytic therapy (50 mg r-tPA) plus GPIIb/IIIa receptor blockers (tirofiban) infusion. The infarct related artery was observed patent fully in angiography at fifth day of hospitalization. In conclusion we think that half dose thrombolytic therapy plus GPIIb/IIIa receptor blockers infusion is a good alternative in stent thrombosis in patients with low bleeding risks. ©2008, Firat University, Medical Faculty