Wernicke’s Encephalopathy (WE) is an acute onset disease characterized by ophtalmoplegy, ataxia and confusion. Thiamine (B1) deficiency is responsible essentially from etiology. In this article, we represent a case of WE following the methanol ingestion. A 39 year old right-handed male patient was brought to emergency department with nausea, vomiting, nonsense talking, and imbalance in walking after drinking 300 cc cologne contenting methanol. On admission, the patient was awake but he was apathic and disorientated. He had a global amnesia, ataxia, diplopia and nystagmus. A short time later, he developed decreased sight findings. The patient’s cranial MRI relieved the thalamic and cerebellar intensity changes. The patient was treated with a thiamine cure and in the third day he totally recovered. We think that WE may develop following methanol ingestion and early treatment is important in the prognosis.