Aim: The aim of this study was to examine excreatory-secretory (E/S) proteins obtained from mature F. gigantica by sodium dodecyl sulfide-polyacrylamide gel electrophores (SDS-PAGE) method.

Materials and Methods: F. gigantica was obtained from bile ducts of infected sheep. In the SDS-PAGE, 10% separating gel was used and separation process was completed 150 V in 3.5 hours.

Results: At the end of the SDS-PAGE examination, two extensively dense protein bands, approximately 65 and 70 kDa in size were visualised.

Conclusion: We believe in that Fasciola gigantica cases can be diagnose in Turkey when the diagnostic methods are used routinely providing effective laboratory facilities to the clinicians.