Different organ dysfunctions may be seen in mushroom poisoning. However, acute pancreatitis is a rare complication of mushroom poisoning. Sixtysix years old women admitted to emergency department 24 h after wild mushroom ingestion with complaints of nausea, vomiting and abdominal pain. The epigastric discomfort was determined in initial examination. It was determined the elevated serum hepatic transaminases, amylase and lipase levels on admission. Computerized tomography of the abdomen showed minimal peripancreatic fluid. The patient was diagnosed as acute pancreatitis and mushroom poisoning and he was observed in emergency intensive care unit. Hepatic transaminases and pancreatic enzymes levels were progressively decreased and the clinical course was good during the observation period. The patient recovered without complication and was discharged from the hospital. Early symptoms of mushroom poisoning and acute pancreatitis are similar. Possibility of acute pancreatitis as well as other organ dysfunctions should be investigated in patients with mushroom poisoning. Early recognition and appropriate therapy for acute pancreatitis and mushroom poisoning may lead to an improved prognosis and complications.