Objective: Renal cell carcinomas, the most common malignant kidney tumor, ranks third among urological tumors. The patients with renal cell carcinoma usually have bad prognosis. In this study, in the samples prepared by nephrectomy materials belonging to incidents with renal cell carcinoma, by comparing P53 ve Ki-67 immunohistochemically, AgNOR's chromophobe qualities histochemically, it was aimed to evaluate the benefit of them as prognostic criteria.

Materials and Methods: Nephrectomy materials diagnosed with renal cell carnicoma were taken into study between 1994 and 2002 in our department. Sections of 54 incidents were looked into and diagnoses were confirmed. Prognostic factors were re-evaluated. Ki-67 P53 and AgNOR chromophobe methods were applied to the prepared sections as immunohistochemically.

Results: Ki-67 PI was determined to be 4.55% in transparent RCC, 3,33% in granular RCC, 3,66%in chromoplobe RCC, 28,7% in fusiform cell carcinoma,0,3% in cystic RCC, and it was found out that Ki-67 PI displayed differences according to histopathological types in renal cell carnicomas. There was a significant difference between PI of fusiform RCC and PI of other types of RCC (p<0.001).

Conclusion: In conclusion, we decided to that the parameters as prognostic factors, because of studies showing differences between the reliability in determining the prognosis was not enough.