The lipoma is a circumscribed mesenchymal tumor originating from adipose tissue. Benign fatty tumors can arise in any location in which fat is normally present. In the head and neck region the posterior subcutaneous neck is the most common site. Intermuscular benign lipoma commonly is found in the anterior abdominal wall, but is rare in the head and neck region. In this case report, we report a 28 years old male with a fluctuated head and neck pain. In the preoperative period mass lesion was not determined with a palpation. Computed tomography showed well circumscribed, intermuscular gaint mass lesion arising from the prevertebral space. The mass was homogeneously hypodense and there was no invasion to the neighboring muscular structures. Fine-neeedle aspiration cytology was found to be mature adipocyts. The lesion was considered a lipoma. In the case antero-posterior surgical approach was applied. After 24 months of follow-up no signs of tumor recurrence or head and neck pain were noted.