In this case report aimed to present a 27-years old diabetic pregnant woman with candida esophagitis caused by Candida krusei. Because of refractory nause, vomiting and unanswered to empiric treatment for upper respiratory tract bacterial infections, gastroscopy was performed and candida esophagitis was diagnosed. Empirical fluconazole treatment was started. At fourteenth day of fluconazole treatment her symptoms did not resolve and candida crusei was identified from endoscopic tissue culture therefore her treatment was accepted fluconazole resistant and treatment was changed to caspofungin. Follow-up nausea, vomiting, difficulty swallowing decreased but had been going on sometimes. Patient's treatment was completed at 81 days. At the end of the treatment her signs and symptoms disappeared. In conclusion, candida esophagitis should be considered among the differential diagnosis of pregnant patients who are nonrespondent to symptomatic treatment for refractory nause, vomiting and weight loss. Additionally etiologic agent and disease progress can be different and therapy should be planned long time considering underlying disease.