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Fırat Tıp Dergisi |
2011, Cilt 16, Sayı 2, Sayfa(lar) 100-101 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
Imatinib (Gleevec) Induced Worsening of Pericardial Effusion in CML |
Dalia HAMMOUD1, Mazen SHAHEEN2, Rayane NASSAR1 |
1Kansas University School of Medicine-Wichita, Internal Medicine, Wichita/Ks, USA 2University of Memphis, Cardiology, Memphis/Tenessee, USA |
Gleevec (imatinib mesylate) is indicated for the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid
leukemia (CML) in chronic phase. Gleevec is often associated with edema and occasionally serious fluid retention. Severe fluid retention (e.g., pleural
effusion, pericardial effusion, pulmonary edema, and ascites) reactions were reported in 1.3% of newly diagnosed CML patients taking Gleevec, and
in 2%-6% of other adult CML patients taking Gleevec. We report a case of a patient with CML and a pericardial effusion worsening after initiating
Gleevec.
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