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Fırat Tıp Dergisi
2013, Cilt 18, Sayı 1, Sayfa(lar) 057-060
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Pulmonary Langerhans' Cell Histiocytosis: Report of Six Cases
Cengizhan SEZGİ1, Abdurrahman ABAKAY1, Ayşe DALLI1, Şevval EREN2
1Dicle Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Diyarbakır, Türkiye
2Dicle Üniversitesi Tıp Fakültesi, Göğüs Cerrahi Anabilim Dalı, Diyarbakır, Türkiye

Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare pulmonary interstitial disease. In this report between January 2004 and December 2009 treated by the Dicle University Faculty of Medicine PLCH patients records were retrospectively studied. We found six PLCH patients. Two of six were female and four male. Mean age was 28,2± 7,3. There were only lung invoment in three, lungs and the pituitary involvement in two, lung,and skin involvement in one. Diagnosis of PLCH was established by video-assisted thoracoscopic surgery in three cases, by open lung biopsy in two and in a case by skin biopsy. There were smoking history in five cases. Dyspnea and cough were the most frequent symptoms. Most obvious lung function test paterns were obstruction and DLCO diminished. Most seen radiological abnormalities were cystic lesions on chest X-ray and nodulary-cystic lesions on HRCT. Two of them were upon cessation of smoking. Prednisolone was given three patients. Complete remission was observed and steroid therapy was stopped in six months. Desmopressin was started for two patients with diabetes insipidus and complete clinical improvement was observed after one month . PLCH should be considered when smoking history with young patient and multiple cystic lesions radiographycally present. It should be awaiken in the view of other organ involvement.

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