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Fırat Tıp Dergisi
2013, Cilt 18, Sayı 2, Sayfa(lar) 088-093
[ Turkish ] [ Tam Metin ] [ PDF ]
The Importance of Thrombophilic Factors in Early Pregnancy Losses
Serdar ŞEN1, Deniz HIZLI2, Yasemin TAŞÇI3, Serdar DİLBAZ3
1Zonguldak Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Kadın Hastalıkları ve Doğum, Zonguldak, Türkiye
2Fatih Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum, Ankara, Türkiye
3Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum, Ankara, Türkiye

Objective: The aim of the present study was to investigate the role of thrombophilic factors in fetal losses at 10-16 gestational weeks.

Materials and Methods: Between April 2003 and May 2004, 50 women who were hospitalized due to fetal loss at 10-16 gestational weeks were defined as study group and 50 women with at least 1 healthy term infant and had no previous miscarriage history were defined as control group. Activated protein C resistance, anti-thrombin III deficiency, protein S deficiency and the presence of anticardiolipin antibodies were evaluated. Chisquare test and independent sample t-test were used for statistical analysis. The cut-off value for statistical significance was set at p <0.05.

Results: The groups were similar with regard to mean serum antithrombin III, anticardiolipin antibodies and protein S level. However, activated protein C resistance was more frequent in the study group (22% vs 6%, p=0,047). Moreover, thrombophilia prevelance was higher in study group when compared to control group (42% vs 16%, p=0.001).

Conclusion: High prevelance of of thrombophilia found in patients with fetal loss at >10 gestational weeks suggests that thrombophilia screening should be a part of the management of these patients.


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