Giant condyloma acuminatum, also known as Buschke-Löwenstein tumor that occurs in ano-genital region and transmitted by sexual way. Giant condyloma acuminatum is an indolent cauliflower-like tumor, but unlike simple condyloma, it is locally aggressive and destructive. In spite of its histologically benign appearance, it may behave malignantly. We present in this report a 55 years old married male with giant condyloma located at the involving penis, scrotum, perineum, and inguinal region. An extensive and aggressive surgical excision was performed. The entire wound was repaired with a split thickness graft. He was healthy without any evidence of tumor at the end of four postoperative years.