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Determination of Bordetella pertussis Seroprevalence and Colonization in Adolescents
Gülşen ERSÖZ1, Özlem TEZOL1, Asuman AKAR2, Semra ERDOĞAN3, Gönül ASLAN4, Necdet KUYUCU2
1Mersin Üniversitesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Mersin, Türkiye
2Mersin Üniversitesi, Çocuk Enfeksiyon Hastalıkları Bilim Dalı, Mersin, Türkiye
3Mersin Üniversitesi, Biyoistatistik ve Tıbbi Bilişim Anabilim Dalı, Mersin, Türkiye
4Mersin Üniversitesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Mersin, Türkiye
Keywords: Adolesan, Pekiştirme, Boğmaca, Seroprevalans, Aşı, Adolescent, Booster, Pertussis, Seroprevalence, Vaccine
Summary
Objective: Pertussis is a contagious respiratory disease caused by Bordetella pertussis (B. pertussis) which can affect all age groups. We aimed to identify B. pertussis infection and determine age-specific antibody levels and provide epidemiologic data for national immunization strategies.

Material and Method: Children aged 10-18 years with cough were examined for B. pertussis PCR (polymerase chain reaction), nasopharyngeal specimen culture, serum B.pertussis IgG by ELISA (enzyme-linked immunosorbent assay).

Results: Of 429 subjects, mean age was 13,04 ± 2,16 years; 229 (53,4%) were male, 200 (46,6%) were female. Cough duration’ median was 4 days (minimum 1 day and maximum 90 days). Of 405 (94%) fully vaccinated children, we accepted 27% of subjects were applied five, 67% were applied four doses of B.pertussis. Since fifth dose of B.pertussis is applied in school age, we accepted all subjects in appropriate age had five doses with hesitation. Subjects were negative for the culture. Three subjects (0,69%) were positive with B. pertussis PCR. Forty three subjects (10%) were posi-tive for B. pertussis IgG. There was a linear correlation between age and B.pertussis IgG absorbance value (r =0,112; p =0,020). Cough duration was significantly longer in B. pertussis IgG positive group compared to those negative (p =0,012). The highest seropositivity was in 13-15 ages.

Conclusion: To decrease the frequency of pertussis infection, to prevent pertussis infection transmisson to infants via adolescents; we recommend sustaining infanthood vaccinations and applying a booster dose at 10-13 years of age in addition to the fifth dose.

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