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Fırat Tıp Dergisi
2015, Cilt 20, Sayı 1, Sayfa(lar) 025-028
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Multiple Renal Arteries in Patients with Kidney Transplantation: Initial Experiences of The New Kidney Transplant Center
Sertac USTA, Vural SOYER, Barıs SARICI, Turgut PISKIN, Bulent UNAL
Inonu University Faculty of Medicine, Department of General Surgery, Malatya, Turkey
Keywords: Kidney transplantation, Multiple arteries, Ischemia, Böbrek nakli, Çoklu arter, İskemi
Summary
Objective: Multiple renal artery grafts of kidney transplant patients developing complications and results for long-term kidney function were evaluated.

Material and Method: From 2010 to 2014, 115 kidney transplant patients were evaluated retrospectively. A sum of, 115 donor nephrectomies were performed in our instution. Kidney were transplanted with a single artery to 99 patients and sixteen (approximate 14%) with more than one. For five of these 16 patients, the organs were transplanted from a cadaver and eleven were transplanted from living donors.

Results: Mean age was 38,5 years (range 9–58 years), mean follow up time was 22,5 month (min. 3,5 and max. 41 month) and mean cold ischemia time was 153 minutes for living donor transplantations and 1396 minutes for cadaveric transplantation, and also warm ischemia time was 236 seconds for living donor transplantation. In all cases, the grafted kidney began to function immediately after reperfusion. Fourteen of the recipients had no any early kidney dysfunction, a problem that is usually attributed to prolonged anastomosis time.

Conclusion: Transplanting kidneys with multiple renal arteries may result in significant risks. Prolonged cold or hot ischemia time may elevate incidence of non functional graft and rejection. Results of this study points that unifying artery anastomosis at the backtable would reduce the risk.
  • Top
  • Summary
  • Introduction
  • Methods
  • Results
  • Disscussion
  • References
    • Introduction
    Renal transplantation is the current definitive treatment option for end stage renal failure1 due to developing of surgical techniques and postoperative immunosuppression.

    In developing countries, major sources of transplanted organs are living donors. Donors are evaluated for renal vascular abnormalities with computerized tomography (CT) or magnetic resonans imaging (MRI) preoperatively. Most common vascular abnormaliy is existence of multiple renal arteries. This means that previous contraindications in the past are currently just one more challenge to overcome. Their existence results in prolongation of operation time and may increase risk of graft failure (tubular necrosis, delayed graft function and even rejection)2,3.

    The aim of this study is to search outcome and complication rate differences of patients with only one artery and with multiple arteries compared with the relevant literature.
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  • Summary
  • Introduction
  • Methods
  • Results
  • Disscussion
  • References
    • Methods
    We performed 115 Kidney Transplantation from living and cadaveric donors from November 2010 to March 2014. Detailed clinical history was taken and physical examination was performed to the recipients. All living donors were evaluated according the criteria of Amsterdam Forum4 Human leukocyte antigen (HLA) typing and tissue crossmatch between donors and their recipients were carried out just before transplantation. All patients and their donors were of compatible blood groups. Routinely methylprednisolone (MP) was delivered just before surgery as induction immunosuppression. Prophylactic antibiotics and low-molecular-weight heparin were delivered to all patients. Recipient bladders were lavaged with 300 mL gentamycin added saline solution and about 200 mL of this solution was retained in the bladder cavity by clamping Foley catheter.

    There are only two transplant surgeons in our kidney transplant team. Therefore, transplantation procedure begins with the donor nephrectomy. As soon as dissection is completed implantation area is prepared, which is extraperitoneally located on the right or left iliac fossa of recipient. Following donor nephrectomy, we immediately began implantation procedures of recipient. All renal vessels were anastomosed to external or common iliac vessels in an end-to-side fashion, using a continuous 6–0 polypropylene suture. In two children recipients, we anastomosed one face of renal artery with continuous suture and the other face of renal artery with one-by-one suture technique. There were some artery abnormalities. These abnormalities were evaluated in terms that correction techniques applied, to the effect of postoperative graft life and other complications. Seven of these patients who had one more renal arteries were female (%44) and nine were male (56%) and mean age was 37,8 (range 9-58). Infive5 of the cases, organs were transplanted from a cadaver and eleven were transplanted from living donors. In seven cases, common arterial orifice (CAO) was created (Figure 1) followed by end to side anastomosis, in the other 9 patients, each artery were individually end to side anastomosis (Figure 2). Recipients and their donors were followed in the transplant clinic during whole hospitalization. Fluid replacement was given according to urine output at postoperative first night and balance was ensured by about +500 or +1000 mL (amount of fluid delivery volume more than urine drainage fluid). Oral fluid intake was ensured in the six to eight hours postoperatively. Intravenous fluid replacement was decreased on the first postoperative day and generally was stopped on the second day. Complete blood count, coagulation profile, and routine biochemistry tests including renal function tests were performed at the same night of the operation and daily during hospitalization. Immunosuppressive drug level was controlled and regulated on postoperative day two and then daily in this period. Transplanted kidneys were not radıologically imaged routinely in the postoperative hospitalization period. Patients were followed by outpatient nephrology clinic after being discharged.


    Click Here to Zoom    		 Figure 1: Description of common arterial orifice.


    Click Here to Zoom    		 Figure 2: Description of end tos ide anastomosis.

  • Top
  • Summary
  • Introduction
  • Methods
  • Results
  • Disscussion
  • References
    • Results
    Double renal artery kidneys were transplanted to sixteen of 115 recipients. Of these, male to female ratio was 9:7. mean age was was 38,5 years (range 9–58 years). Four patients and their donors had three HLA mismatches. Two patients had two HLA mismatches. Two patient had four mismatches, two patients had five mismatches, three had six mismatches, three had one mismatch Blood groups of recipient and donor and causes of ESRD in patients are shown in Table 1. Left kidney donor nephrectomy was preferred when possible. In case of vascular problems or any other contraindication right kidney nephrectomy was performed. Left donor nephrectomy to right donor nephrectomy ratio was 13:3. Right iliac fossa was usually preferred for implantation in recipients. In case of a vascular problem or a surgical necessity such as native nephrectomy or possible pancreas transplantation in future, left iliac fossa was chosen. The right iliac fossa was used in all of recipients On the 16 patients who had double renal arteries, mean hot ischemia time was 235.8 second on living donor renal transplanted, mean cold ischemia time was 152 minute on living donors and was 1396 minutes on cadaveric donors. Mean urination time after transplantation was 6,8 (2-20) minutes. Urine output began immediately after vascular anastomosis. Mean time of discharge from hospital was postoperative day 8 (range 4–18 days). As an induction immunosuppression antithymosite globulin or basiliximab treatment was initiated. Tacrolimus, mycophenolate mofetil, or enteric coated mycophenolate sodium and corticosteroid were given to recipients as postoperative immunosuppressive drugs. Trimethoprim sulfmethaxazole and valganciclovir were used for prophylaxy. Acyclovir prophylaxy was given child patients instead of valganciclovir. Calcium vitamin D3 were given for replacement treatment. There was no significant difference in the occurrence of vascular and urologic complications, as well as delayed graft function, when we compared grafts with single and multiple arteries. In all cases, the grafted kidney began to function immediately after reperfusion. Fourteen of the recipients had no any early kidney dysfunction, a problem that is usually attributed to prolonged anastomosis time. One of the patients had increased liver enziymes on postoperative term, and resolved with a regulation of immunosuppressive therapy dosage. Another one had seizures and wound swelling on postoperative 8 days that was discharged. Creatinine level analysis result of the wound aspiration material was 5 mg/dL . Whereupon, the patient was reoperated. Transplanted kidney were minimally functional. Kidney biopsy (Bx) tissue samples were taken. Bleeding was occurred. Urinary leakage was observed. Urine leakage from transplanted kidney was treated with a nephrostomy catheter and double J stents. Immunosuppressive treatment dosages were altered to esolve convulsions. In another case with a cadaveric kidney, the drainage tube material was haemorrhagic. There was subcutaneous hematoma and lack of urinary output. The patient was reoperated three times after transplantation. Due to impaired haemodynamic status, patient was taken to the intensive care unit and died on postoperative day five. Another patient died on postoperative day 38 due to another problem. Transplanted renal arteries were patent in all of other cases.


    Click Here to Zoom    		 Table 1: Recipient and donor demographics and transplantation releated parameters

  • Top
  • Summary
  • Introduction
  • Methods
  • Results
  • Disscussion
  • References
    • Discussion
    Complex vascular anatomy has always posed a challenge to the surgical skills of the operating team5. Previous studies showed that incidence of multiple renal arteries in the general population is 18% to 30%6. In our experience, the incidence of multiple renal arteries was 16 %. Transplanting a kidney with multiple renal arteries has several disadvantages, including prolonged warm ischemia time, high incidence of acute tubular necrosis and rejection episodes, high graft function failure, and prolonged hospitalization. Multiple renal arteries have reportedly been associated with a higher rate of vascular complications, including arterial thrombosis and renal artery stenosis6-9. Several techniques for bench or in situ reconstruction of multiple renal arteries have been described in order to reduce the incidence of these vascular complications10. In grafts from cadaver donors, the Carrel aortic patch is the standard technique of vascular reconstruction in renal transplants with a single and multiple arteries11. In kidney transplants with multiple anastomoses, revascularization can be done either simultaneously after the entire arterial engraftment is completed or sequentially. Using the latter technique, the main renal artery is revascularized first. Then, the vascular clamps are released and the kidney is partially revascularized. The other artery is anastomosed to a convenient site, maintaining perfusion of the kidney by the main artery. Even though an aortic patch theoretically should make the vascular anastomosis easier and prevent stenosis, the presence of a patch did not decrease the incidence of renal artery stenosis for grafts with a single artery. The other complications are posttransplant hypertension, rejection, urologic complications, such as ureteral necrosis or calyceal cutaneous fistulas related with delayed graft function.

    Therefore, kidneys with multiple arteries should be implanted, using the technique that best fits a particular situation and with which the individual transplant surgeon feels most comfortable.
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  • Summary
  • Introduction
  • Methods
  • Results
  • Discussion
  • References
    • References

    1) Abbaszadeh S, Hossein Nourbala M, Alghasi M, Sharafi M, Einollahi B. does renal artery multiplicity have ımpact on patient and allograft survival rates? Nephro-Urol Mon 2009; 1: 45-50.

    2) Kumar A, Gupta RS, Srivastava A, Bansal P. Sequential anastomosis of accessory renal artery to inferior epigastric artery in the management of multiple arteries in live related renal transplantation: a critical appraisal. Clin Transplant 2001; 15: 131-5

    3) Khan TT, Koshaji B, Kamal S, Akhtar F, Rahman E. Multiple renal arteries in living donor kidney transplantation: Limits of recipient warm ischemia. Saudi J Kidney Dis Transpl 2014: 25, 651.

    4) Delmonico F. Council of the transplantation society: a report of the amsterdam forum on the care of the live kidney donor: data and medical guidelines. Transpl 2005; 53: 79.

    5) Miura M, Seki T, Harada H, et al. Clinical evaluation of donor renal artery reconstruction in kidney transplantation. Transplant Proc 1996; 28: 1611-15.

    6) Oesterwitz H, Scholz D, Kaden J, Mebel M. Prolongation of rat renal allograft survival time by donor pretreatment with 8-methoxypsoralen and longwave ultraviolet irradiation of the graft (PUVA therapy). Urological research 1985; 13: 95-8.

    7) Roza AM, Perloff LJ, Naji A, Grossman RA, Barker CF. Living-related donors with bilateral multiple renal arteries. A twenty-year experience. Transpl 1989; 47: 397-9.

    8) Guerra EE, Didone EC, Zanotelli ML, Vitola SP, Cantisani GP, Goldani JC, Garcia VD. Renal transplants with multiple arteries. In Transplantation proceedings 1992; 24-5: 1868.

    9) Benedetti E, Troppmann C, Gillingham K, Sutherland DE, Payne WD, Dunn DL, Grussner RW. Short-and long-term outcomes of kidney transplants with multiple renal arteries. Annals Surgery 1995; 221: 406.

    10) Hashimoto Y, Nagano S, Ohsima S, et al. Surgical complications in kidney transplantation: experience from 1200 transplants performed over 20 years at six hospitals in central Japan. Transplant Proc 1996; 28: 1465-7.

    11) Kocak T, Nane I, Ander H, Ziylan O, Oktar T, Ozsoy C. Urological and surgical complications in 362 consecutive living related donor kidney transplantations. Urol Int 2004; 72: 252-6.
  • Top
  • Summary
  • Introduction
  • Methods
  • Results
  • Discussion
  • References
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