Main findings
We have reviewed the conservative treatment methods and results of the patients diagnosed with placental invasion anomaly retrospectively in this study. We observed that, UBT apparatus was effective for controlling hemorrhagia due to placental invasion anomaly. In some of our cases, we applied methods such as square or Affronti sutures and uterine artery ligation in addition to UBT.
Strength and limitations
Obstetric hemorrhage is one of the major reason of maternal mortality10. Also in our clinic, previously, for the cases with placental invasion anomaly, uterine or internal iliac artery ligation methods were applied as a first choice and hysterectomy was applied for the cases where the bleeding continued. However, recently we have applied UBT for these cases and our morbidity rate has significantly decreased and none of our cases died due to placental invasion anomaly.
The clinical presentation of placentation anomalies may differ. Placenta percreta is the most serious one among these, due to uterine rupture and subsequent hemorrhage risk. However, placenta accreta and increta also constitute increased bleeding risk. Miller et al. have measured the estimated blood loss volume during placenta accreta related cesarean hysterectomy in a group of 62 patients1. The reported blood loss volumes were as follows: 2000 mL in 41 patients, 5000 mL in nine patients, 10000 mL in four patients and 20000 mL in two patients. Despite our low study population, the highest blood loss volume was 2700 mL and our mean blood loss volume was 1950 (800- 2700) mL. The low bleeding volume in our study may arise from UBT application without trying any other invasive method. However, one of our cases received uterine artery ligation combined with B-Lynch suturation, but the bleeding continued and urgent hysterectomy was applied on this case by re-operation due to DIC development. During this patient's term, we have not yet started to use the UBT tools in our clinic.
Interpretation
Canonico et al. states that following catheterization of descendant aorta prophylactically by transhumeral or transphemoral access; B-Lynch suturation + Bakri balloon application “sandwich method”11 combined with Affronti sutures is effective for PPH control12. By application of intra-aortic balloon from distal descendant aorta, vascularization of uterus is provided by ovarian arteries. Catheterization of aorta from upper parts may disrupt uterine perfusion. Furthermore, a qualified radiologist is required for this procedure. We have provided uterine de-vascularization by applying uterine artery ligation together with triple tourniquet method to the istmic region, infindibulopelvic region and cervical region of a case with placenta percreta (Case no.3 in Table 1). Removal of placental tissue of this case was performed by curettage later. After curettage of placental tissue, we were able to control bleeding by inflating Bakri balloon 500 mL. Also this method may be applied in clinics where a qualified radiologist is not available to apply invasive procedure. In another case with placenta percreta (Case no.5 in Table 1), we applied Affronti suture and then Bakri balloon together with square sutures. In this case, there were dense intrabdominal adhesions due to previous repeated cesarean sectios. Optimal exploration of the pelvic region and determination of the borders of the bladder were very difficult. Therefore we inflated the bladder with methylene blue using foley catheter. We were able to perceive the borders of the bladder only by feeling the coldness of the installed blue into bladder and then were able to apply the Affronti sutures. We were not able to insert B-Lynch compression suture on uterus due to abdominal adhesions. Furthermore, we used condom combined foley catheter as UBT tool. Also in this case, PPH was taken under control, no hysterectomy was required and no infection had occurred. In similar cases, application of UBT together with Affronti sutures instead of B-Lynch suture may also be effective.
In insufficient clinic opportunities, PPH treatment modalities such as uterotonics, transfusion of blood products and surgical intervention are generally limited. In a systematic review, 241 women with complaint of PPH were analysed for treatment modalities (six case reports or case series, five prospective studies and two retrospective studies for a total of 241 women). They reported that UBT successfully treated PPH in 234 out of 241 women and they strongly suggested that UBT is an effective treatment method in PPH treatment13. In studies conducted until today, it is stated that UBT is useful for management of PPH which occurs secondarily to uterine atonia, coagulopathy, rest placenta, placenta previa and placenta accrete14. In our clinic we observed that UBT is effective in all cases with invasion anomaly for controlling PPH, together with additional suturation procedures in some cases. The advantages of UBT confirmed in our clinic are short period of operation, less morbidity and infection, decrease in transfusion amount, ease of application and non-requirement of advanced surgical ability. Furthermore, particularly in cases with dense pelvic adhesions due to previous abdominal operations, it may be difficult to be able to apply suture techniques such a B-Lynch. Application of UBT, will both decrease loss of time and loss of blood for these cases. Also no need to obtain assistance from another surgical branch may be another advantage of UBT.
Tindell et al. have reviewed eight studies in which condom catheter is used for PPH. Only in seven of 193 cases, the procedure was unsuccessful. The complication rates have found to be low in all types where UBT was used. No uterine rupture and no increase in infection risk had been reported13. We provided hemorrhage control in a case with percreta by applying foley catheter-condom in a clinic which did not have Bakri balloon. In cases when Bakri balloon is not available, foley catheter-condom can also provide effective uterine tamponade. Georgiou showed that it was not necessary for the pressure inside the balloon to be above the systemic pressure15. Furthermore, in five controlled PPH cases, a foley catheter inflated with 30 mL has been used. Therefore, it was stated that the impact mechanism of UBT may comprise not only tamponade but also release of natural prostaglandins. We observed that Bakri balloon tamponade with 150-250 mL instillation volume was also effective for preventing hemorrhage. The effect of balloon tamponade may be searched for lower volumes. When we gradually brought down and up the UBT tool during the first 48th hour of operation, we observed that PPH was controlled in most of our cases. Only in two cases, UBT tool was maintained for more than 48 hours. Our main problem experienced during Bakri balloon applications was extraction of the balloon from uterus due to cervical dilatation. For preventing the extraction of balloon, we performed vaginal packing and insertion of cervical pursing suture.