Fırat Tıp Dergisi

Objective: Myasthenia Gravis (MG) is an immune-mediated disease characterized by fluctuating weakness throughout the day, affecting postsynaptic nerve conduction at the neuromuscular junction. We aimed to retrospectively evaluate the data of patients with a preliminary diagnosis of MG who underwent repetitive nerve stimulation test (RNS) and single fiber electromyography (SFE). Material and Method: The medical records of 347 patients who were referred to the Electromyography (EMG) Laboratory of Harran University Faculty of Medicine Hospital with a preliminary diagnosis of myasthenia gravis (MG) and underwent ASU or TLE between 2018 and 2023 were retrospectively reviewed in electronic format. Demographic data (age, sex), presenting symptoms, acetylcholine receptor antibody (AChR) status, and electrophysiological findings of the patients were recorded.

Results: Forty-eight of 347 patients were diagnosed with MG. The mean age of the patients was 50.1 (17.95) in the MG group and 36.49 (15.67) in the MG-negative group. The most common reason for EMG was ptosis. Ninety (26%) patients had only RNS, 131 (38%) patients had only SFE, and 126 (36%) patients had both. The sensitivity of SFE and RNS for the diagnosis of MG was 73% and 41% in ocular MG and 100% and 82% in genera-lized MG, respectively.

Conclusion: It should be kept in mind that history and examination are the cornerstones for the clinician for the diagnosis of MG and electro-neurophysiological tests are helpful in the diagnosis in appropriate patients. In EMG laboratories, patients should be questioned carefully regarding MG and unnecessary orders should be avoided to allocate sufficient time to the real patient.


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