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Fırat Tıp Dergisi |
2007, Cilt 12, Sayı 2, Sayfa(lar) 093-096 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
Effects of Epigallocatechin 3- Gallate in Rat Cardiac Tissue on Oxidant and Antioxidant System Exposed to Sevoflurane Anesthesia |
Ayşe Belin ÖZER1, Dilara KAMAN2 |
1Mardin Devlet Hastanesi, Anestezi Uzmanı, MARDİN 2Fırat Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, ELAZIĞ |
Objectives: To investigate the possible effects of sevoflurane anesthesia and epigallocatechin 3- gallate (EGCg) on cardiac tissue by evaluating the
oxidant and antioxidant status in rats.
Materials and Methods: Tree groups of animals were studied. Sevoflurane 3% (v/v) in air/O2 were administered to animals in group 1 (n = 6) and sevoflurane plus EGCg was administered in group 2 (n = 6). Six animals were allocated to control group (group 3). Malondialdehyde (MDA), nitric oxide (NOx), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in cardiac tissue were studied. Results: In group I, MDA, SOD and GSH-Px levels were significantly increased (p<0.05, p<0.0001, p<0.001, respectively) while non-significant changes occurred in CAT and NOx activities. Supplementation of EGCg (group 2) decreased the MDA, SOD and GSH-Px activities whereas, the NOx activities increase with EGCg supplementation. Conclusion: The amount of lipid peroxidation and antioxidant enzyme levels were more increased in following sevoflurane administration. The administration of intravenous EGCg significantly protected cardiac tissue. ©2007, Firat University, Medical Faculty |
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