Tobacco, alcohol, and substance addiction starts in adolescence and often lasts for life. This study aims to research the prevalence of cigarette, alcohol, and substance use among the students of Kırklareli University. Material and Method Of the 9,698 students studying at Kırklareli University for the spring term 2010-2011, 902 were using the proportional stratified sampling method. their lives, while lower than in western countries, is not insignificant. For the health services that will be provided to the university students it would be appropriate to include the services that would support them to refrain from the drug addiction materials.