Other physical examination findings were normal, and a detailed neurologic examination was performed. The patient was in a stuporous state and exhibited a flexor response to painful stimuli. Pupils were of equal in size and reacted normally to light. Both foot plantar reflexes elicited no response. No abnormal reflexes or signs of neurological improvement were observed after 20 minutes of glucose infusion. Due to the lack of neurological improvement and the patient's risk factors, non-contrast brain tomography and DWI were performed. The DWI and apparent diffusion coefficient (ADC) mapping revealed symmetric bilateral butterfly-shaped areas of restricted diffusion in the periventricular white matter near the splenium of the corpus callosum and lateral ventricles (Figure 1).

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Figure 1: DWI and ADC imaging taken at the time of admission to the emergency department (Hyperintense lesions are clearly observed).

The patient was admitted to the intensive care unit and received meticulous monitoring of their blood glucose levels. Dextrose support was no longer necessary after 10 hours, but there was limited progress in the patient's neurological examination until the 48th hour. Following this, a DWI and ADC mapping were conducted, showcasing a complete resolution of the lesions (Figure 2).

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Figure 2: DWI and ADC imaging of the patient taken 48 hours later (Hyperintense lesions have disappeared).

Despite the encouraging findings, the absence of neurological improvement prompted concerns about non-convulsive status epilepticus, although the electroencephalography results returned normal. Over the course of 20 days in intensive care, the patient's neurological condition showed gradual improvement, culminating in complete neurological recovery after six months with the aid of physical therapies.

In contrast to ischemic stroke, hyperintense lesions can also be observed in a variety of other conditions. These include toxicity, withdrawal from antiepileptic drugs, seizures, infectious encephalitis, cerebral edema due to high altitude, alcohol use, hemolytic uremic syndromes, as well as metabolic disorders such as hypernatremia and hypoglycemia^3-5.

Lesions on DWI caused by hypoglycemia can typically appear in different areas, such as the basal ganglia, pons, temporal and occipital cortices, and hippocampus^3,6,7. Contrary to what was previously known, a study has shown that white matter was more sensitive to hypoglycemia. However, white matter, gray matter, or coinvolvement do not seem to correlate clearly with the clinical outcome⁸.

In some rare case series, it has been reported that corona radiata, centrum semiovale, and internal capsule parts of the white matter were involved¹. Considering hypoglycemia in the differential diagnosis is imperative, given the substantial disparities in managing and treating ischemic infarction and other metabolic causes, in order to avert deleterious outcomes⁹. In our case, as seen in most cases of hypoglycemia, a symmetric bilateral lesion with more intense involvement of the white matter, hyperintense on DWI, and hypointense on ADC mapping was observed (Figure 1).

In the neurological examination of the patient, metabolic causes were considered in the foreground, and correction of profound hypoglycemia was planned because of the presence of stupor-like disturbance of consci-ousness, feeble motor response to central painful stimuli, and equal flexor response in four extremities in the absence of lateralizing findings.

However, although the clinical improvement was insufficient at 48 hours, the complete disappearance of the lesions was observed in the new DWI and ADC mapping taken for control (Figure 2). Our patient's clinical recovery occurred after approximately 20 days of intensive care treatment, and complete neurological recovery was achieved after six months. As in the study by Ma et al., the clinical status of our patient at the time of presentation and the observation of restriction in DWI suggested that she was exposed to profound hypoglycemia⁸.

As a result, the presence of hyperintense lesions on DWI typically signifies ischemic infarction. Nevertheless, it is essential to recognize that numerous other pathologies can also produce hyperintense lesions, as demonstrated in the present case. When physical examination fails to reveal lateralizing findings and bilateral lesions are observed on DWI, consideration should be given to metabolic etiologies aside from ischemic infarction.

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2) Cordonnier C, Oppenheim C, Lamy C, Meder JF, Mas JL. Serial diffusion and perfusion-weighted MR in transient hypoglycemia. Neurology 2005; 65: 175.

3) Doherty MJ, Jayadev S, Watson NF, Konchada RS, Hallam DK. Clinical implications of splenium magnetic resonance imaging signal changes. Arch Neurol 2005; 62: 433-7.

4) Adam G, Ferrier M, Patsoura S et al. Magnetic resonance imaging of arterial stroke mimics: a pictorial review. Insights Imaging 2018; 9: 815-31.

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