Objective: Obesity is known to be one of the most important health problems leading to dyslipidemia. In this study, we aimed to examine the lipid profile changes in the postoperative 6th month of morbidly obese patients who underwent Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Roux-en-Y Gastric Bypass (LRYGB).

Material and Method: Patients who underwent bariatric surgery for morbid obesity between September 2022 and January 2023 at Ministry of Health University Umraniye Training and Research Hospital General Surgery Clinic were retrospectively analyzed. Age, gender and comorbidities of the patients, as well as preoperative period and postoperative 6th month weight, BMI, %EWL, HDL, LDL, cholesterol, triglyceride, glucose and also HbA1c values of individiuals with type 2 DM were recorded.

Results: A hundred twenty-three patients were included in the study and 21 patients were excluded for various reasons, and a total of 102 patients were analyzed. LSG group showed significant increase in LDL, and HDL, and significant decrease in triglyceride, glucose and HbA1c levels at 6th months after the operation (p =0.004, p <0.001, p <0.001, p <0.001, p <0.001, respectively). LRYGB group showed significant decrease in cholesterol, triglyceride, glucose and HbA1c levels at 6th months after the operation (p =0.008, p <0.001, p <0.001, p <0.001, respectively). There was no statistically significant difference between the groups in terms of surgical success rate (p =0.548).

Conclusion: Significant improvements in weight loss, lipid profiles, fasting glucose and HbA1C values occur after both LSG and LRYGB surgeries. Both surgeries reveal effective results in the treatment of patients with hyperlipidemia.