Objective: The incidence of blood and sexually transmitted infections is increased in individuals with alcohol and/or drug use disorder(SUD). We aimed to determine the frequency of Hepatitis B, Hepatitis C, HIV(Human Immunodeficiency Virus) and Syphilis infections in patients with SUD and to evaluate the relationship between the types of drugs and the serological results of these infections.

Material and Method: HBsAg, anti-HBs, anti-HBc IgG, anti-HCV, anti-HIV Ag/Ab and syphilis antibody test results of 2532 patients(>18 years old) with SUD who were followed up as inpatients or outpatients at the AMATEM clinic between 2013 and 2023 were retrospectively examined. Sera were analysed by chemiluminescence immunoassay using Abbott test kits (Architect, Abbott, USA). Patients were grouped into alcohol addiction(G1), opioid addiction(G2) and non-opioid substance addiction(G3).

Results: In G1, G2, G3, anti-HCV 0.85%, 10.86%, 1.93%, anti-HBs 32.17%, 57.85%, 51.66%, anti-HBc IgG 25.8%, 9.28%, 11.86%, HBsAg 2.91%, 1.5%, 1.61%, anti-HIV Ag/Ab 0.36%, 0%, 0.63% and syphilis TP 0%, 0%, 7.69% were found positive. Anti-HCV, anti-HBs and anti-HBc IgG positivity of G1 was significantly different from other groups (p <0.001, p <0.001, p <0.001, respectively). There was no significant difference between the three groups for HBsAg, syphilis antibody and anti-HIV Ag/Ab positivity (p =1.00, p =1.00, p =0.284, respectively). Anti-HCV positi-vity was higher in opioid users than in other groups (p <0.001).

Conclusion: Further investigation is required to elucidate the immunological response associated with hepatitis B infection in alcohol users and the relationship between opioid use and hepatitis C infection. Related patient groups should be screened for infectious diseases and trainings should be provided to increase their awareness.