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Fırat Tıp Dergisi
2008, Cilt 13, Sayı 1, Sayfa(lar) 049-052
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Determination of the Role of Mean Corpuscular Volume Level on the Diagnosis of Alcoholic Liver Cirrhosis and Investigation of Its Effect on the Prognosis
Özgür TANRIVERDİ1, Esen GER2, Sernaz UZUNOĞLU2, M. Kemal SEREZ2, B. Ümit ÜRE2, Kadir ERGEN2, A.Baki KUMBASAR2
1Goztepe Safak Private Hospital, Internal Medicine and Emergency Service, İSTANBUL
2Haseki Education and Research Hospital, 3rd Internal Medicine Clinic, İSTANBUL

Objectives: In this study, we aimed to determine the relationship between macrocytosis and Alcoholic Liver Cirrhosis (ALC) and its accuracy, sensitivity and specificity rates.

Material and Methods: Mean corpuscular volume (MCV) levels of 46 patients diagnosed as having ALC (Group 1) and 51 patients diagnosed as having Hepatitis B cirrhosis and Hepatitis C cirrhosis (Group 2) were compared retrospectively.

Results: MCV level determined as 94.6±10.87 in patients in Group 1 was statistically significantly higher than in patients in Group 2 (p<0.001). Macrocytosis was determined in 26 patients (56.52%) in Group 1 but in 3 patients (5.88%) in Group 2. When the cut-off value for MCV in the diagnosis of ALC was taken as 102 fl, its accuracy, sensitivity and specificity rates for the diagnosis were determined as 78%, 93% and 72% respectively. MCV levels of Child class C ALC patients (n=27) were determined statistically significantly higher than MCV levels of Child class A and Child class B ALC patients.

Conclusion: We concluded that MCV level is an important variable for the diagnosis of ALC but it is insufficient alone for the diagnosis; macrocytosis frequency increases in these patients and MCV levels increase as the prognosis worsens even without existence of anemia. ©2008, Firat University, Medical Faculty


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