Fourtyfive years old patient with parity 1 was admitted hospital due to amenorrhea. She had given birth at home 20 years ago and had severe bleeding due to retained placenta. Her hormonal examination showed panhypopitiutarism. Empty sella was diagnosed by MRI examination. Glucocorticoid, thyroxin and estrogen-progesteron treatment were given. Sheehan’s Syndrome is insufficiency of pituitary and adrenal gland due to postpartum hemorrhage and hypovolemia. Symptoms may develop immediately or after years depending on severity of pituitary destruction. Most prominant symptoms are secondary amenorrhea, loss of lactation, loss of libido and other symptoms due to loss of pituitary reserves. Empty sella is complete or incomplete insufficiancy of hypophysis due to intracellar herniation of subarachnoid structures. One cause of empty sella is pituitary necrosis developing after severe postpartum hemorrhage (Sheehan’s Syndrome). CT and MRI are best methods for diagnosis of empty sella. Hormon replacement treatment (glucocorticoid, thyroxin and estrogen-progesteron) is given to patients with Sheehan’s Syndrome.