Fırat Tıp Dergisi |
2011, Cilt 16, Sayı 2, Sayfa(lar) 102-105 |
[ Turkish ]
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Leigh Syndrome: Cranial MRI and MR Spectroscopy Findings |
Hasan AYDIN, Volkan KIZILGÖZ, Baki HEKİMOĞLU |
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Radyoloji Anabilim Dalı, Ankara |
A 10 years old girl, was admitted to the intensive care unit with seizure, myotonic-clonic jerks in her hands, vomiting, respiratory failure and mild
metabolic acidosis. Brain Magnetic resonance imaging (MRI) and proton MR spectroscopy(MRS) were performed.The MRI findings presented
symmetric basal ganglia, brain stem, left thalamus and subthalamic nuclei involvement. MRS obtained from the basal ganglia and thalamus lesions,
showed increased lactate and choline peak, decreased NAA\Crea and NAA\Cho ratios. In the CSF, there was also increased lactate. These imaging
findings, clinical course and the laboratory data were used for the diagnosis of Juvenile form of Leigh syndrome. Muscle biopsy wasn't needed for
the diagnosis.
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[ Turkish ]
[ Tam Metin ]
[ PDF ]
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