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Fırat Tıp Dergisi
2012, Cilt 17, Sayı 4, Sayfa(lar) 189-195
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The Investigation of Effects of Vitamın C and Benfothiamine on Alterations in The Experimental Diabetic Rat Kidney Tissues
Emir DÖNDER1, Mehmet ÜNAL1, Dürrin Özlem DABAK2, Tuncay KULOĞLU2, Yusuf ÖZKAN3
1Fırat Üniversitesi, İç Hastalıkları Anabilim Dalı, Elazığ, Türkiye
2Fırat Üniversitesi, Histoloji ve Embriyoloji Anabilim Dalı, Elazığ, Türkiye
3Fırat Üniversitesi, Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı, Elazığ, Türkiye

Objective: The protective effects of Benfothiamine and Vitamin C against apopitotic changes in streptozotosin (STZ) induced experimental diabetic rats were investigated.

Materials and Methods: Twenty eight rats were included in the study. The rats were divided into 4 groups as 7 rats in each group. Control group, had no intervention throughout the study. To induce diabetes mellitus (DM) other 3 groups were administered 0.1 M STZ in sodium citrate buffer intraperitoneally. DM group, received no other medication until the end of the study. DM + Benfothiamine group received 70 mg/kg/day Benfothiamine by oral route for a period of 6 weeks. DM+Vitamin C group received 900 mg/kg/day Vitamin C by oral route for a period of 6 weeks. In the end of the experiment, rats were decapitated, renal tissues were obtained and stained with hematoxylen-eosin and Tunel paints.

Results: DM+Benfothiamine group showed mesengial matrix hypertrophy in glomerules, although the increasement was less than the DM group. DM+Vitamin C group also showed increased mesangial matrix and glomerular hyperthrophy. DM+Vitamin C group showed less significant tubuler dilatation, dissociation of tubuler epithelium, and glucogenic vacuolization. This protective effect was not as much as the DM+Benfothiamine group. When compared to control group, DM group had significantly increased Tunel positivity. DM+Benfothiamine and DM+Vitamin C group showed decreased Tunel positivity in comparasion to the DM group.

Conclusion: Benfothiamine and Vitamin C were found to have protective effects on the renal dysfunction induced by DM.


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