Objective: This study aims to examine the relationship between the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocy-te/monocyte ratio (LMR), red blood cell distribution width (RDW), platelet distribution width (PDW) in patients diagnosed with benign, premalig-nant, and malignant laryngeal lesions (BLL, PLL, MLL), whether these have a predictive and prognostic value in terms of healing or progression in the follow-up of PLL.

Material and Method: The files of 213 patients who were operated for laryngeal lesions between 2014 and 2020 were retrospectively analyzed and grouped as BLL, PLL, MLL according to their histopathological diagnosis. According to the lesion localization, they are also grouped as supraglottic, glottic, subglottic, and transglottic; as good and poor prognosis according to healing, recurrence, and cancer transformation status in follow-up. Age, gender, and NLR, PLR, LMR, RDW, PDW from peoperative blood samples were compared between the groups.

Results: The mean age was the highest in the MLL group and the lowest in the BLL group according to the demographic characteristics of the pati-ents (p <0.001). In gender distribution, the male gender is significantly higher in MLL and PLL groups compared to the BLL group (p <0.001). There is no significant difference between the groups in terms of NLR, PLR, LMR, RDW, and PDW values according to the diagnosis, localization, and prognostic features of the lesion.

Conclusion: It was observed that NLO, PLO, LMO, RDW, and PDW values did not show a significant change according to the histopathological classification, localization, and prognosis of the disease.