[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]
Fırat Tıp Dergisi
2002, Cilt 7, Sayı 1, Sayfa(lar) 663-667
[ Turkish ]
SUBACUTE (4-WEEKS) FORMALDEHYDE INHALATION CHANGES SOME ENZYME ACTIVITIES PARTICIPATING IN IMPORTANT METABOLIC PATHWAYS IN RAT LIVER
H. Ramazan YILMAZ1, O. Aslan ÖZEN2, Hüseyin ÖZYURT3, Sadık SÖĞÜT3, Ahmet SONGUR4, Mustafa SARSILMAZ4
1İnönü University Sciences-Arts-Faculty, Department of Biology, MALATYA,
2Karaelmas University, Faculty of Medicine, Departman of Anotomy, ZONGULDAK,
3İnönü Unıversity Faculty of Medicine, Departman of Biochemistry, MALATYA,
4Fırat Unıversity Faculty of Medicine, Departman of Anotomy, ELAZIĞ, TURKEY

Aim: The aim of this study was to evaluate whether some enzyme activities are changed in the liver of rats exposed to subacute formaldehyde (FA) inhalation (4-weeks).

Material and Methods: Thirty male albino Wistar rats were divided into 3 groups randomly (10 for each group). The first group of rats were used as control. Rats were exposed to the atmosphere containing 10 and 20 ppm FA continuously (8 hours per day, 5 days per week) in Groups I and II. Hexokinase (HK), malate dehydrogenase (MDH), lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activities were measured in the liver tissues.

Results: The results showed a remarkable reduction of G6PD activity in the liver tissues from rats exposed to 10 ppm FA for 4-weeks. There were no differences in the activities of HK, 6PGD, MDH, and LDH among study and control groups. It was observed that the G6PD activity reduced and MDH activity increased in liver tissues from rats exposed to 20 ppm FA for 4-weeks. But, there was no difference in activities of HK, 6PGD, and LDH.

Conclusions: FA, as an environmental toxic substance, may interrupt the antioxidant system in liver by blockage the pentose phosphate pathway.


[ Turkish ]
[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]