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Fırat Tıp Dergisi
2022, Cilt 27, Sayı 3, Sayfa(lar) 221-227
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Comparison of Brimonidine Tartarat with and without Preservative on the Ocular Surface of Patients with Glaucoma
1Fırat Üniversitesi, Tıp Fakültesi Göz Hastalıkları Anabilim Dalı, Elazığ, Türkiye
2Akdağmadeni Devlet Hastanesi, Göz Hastalıkları Kliniği, Yozgat, Türkiye
3Van Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, Van, Türkiye

Objective: To compare the shortterm effects of preservative-free and preserved 0.15% brimonidine tartrate on intraocular pressure (IOP) and ocular surface in glaucoma patients.

Material and Method: Forty eyes of 20 patients who were diagnosed with primary open-angle glaucoma in our clinic, had no previous treatment and had no ocular surface disease were included in the study. The first group were started on 0.15% brimonidine tartrate without preservatives, and the second group were started on 0.15% brimonidine tartrate with preservatives. IOP, corneal and ocular surface staining score (Oxford Scale), tear break-up time (BUT), ocular surface disease index (OSDI), and tear meniscus height were evaluated at the first admission of the patients and at the 6th-month follow-up after the initiation of drug therapy.

Results: The mean age of the patients was 57.21±9.29 years. The mean IOP before and after treatment were measured as 21.30±1.72, 20.70±1.69 and 16.35±0.88 mmHg, 15.75±1.65 mmHg, OSDI scores 16.39±8.17, 16.41±8.12 and 28.938.97, 35.05±16.05, respectively. Average BUT 18.603.69, 18.65±3.64 and 13.25±2.38, 11.454.08 sec, average ocular surface staining was 0.20±0.25, 0.180.15 and 0.20±0.41, 0.60±0.68. Mean meniscus height was 320.23±73.94, 315.72±85.92 and 295.24125.12, 285.75±138.45 micrometers. When the first and sixth month results of both groups were compared, there was a statistically significant difference in IOP and ocular surface findings (p <0.05). When the two groups were compared at the sixth-month, there was only a statistically significant difference on the Oxford scale (p <0.05).

Conclusion:Preservative-free anti-glaucomatous therapy may be preferred in glaucoma patients to reduce symptoms related to ocular surface problems, increase effective IOP control and drug compliance.

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