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Fırat Tıp Dergisi
2004, Cilt 9, Sayı 3, Sayfa(lar) 086-090
[ Turkish ] [ Tam Metin ] [ PDF ]
Effects of Rosiglitazon on Homocysteine and Leptin Levels in Patients with Type 2 Diabetes Mellitus Using Metformin
Yusuf ÖZKAN1, Süleyman Serdar KOCA2, Eylem MENGÜCÜK2, Vedat GENÇER2, Emir DÖNDER2
1 Fırat Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı,ELAZIĞ
2 Fırat Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, ELAZIĞ

The prevalence of diabetes mellitus, a chronic progressive disease, is rising seriously. Rosiglitasone from the thiazolidinedion group is an oral antidiabetic extensively used in the treatment of type 2 DM. In this study we aimed to examine the effects of Rosiglitasone treatment on homocysteine and leptin levels.

Material and method:
The study included 20 voluntary patients (15 female and 5 male; mean age 51±12 years; and mean body mass index 28±5 kg/m2) who were diagnosed as type 2 DM and used Metformin, but whose blood glucose could not be regulated (high fasting blood glucose (FBG), postprandial blood glucose (PBG) and HbA1c). 4 mg/day Rosiglitasone was added to Metformin (2 x 850 mg –3 x 850 mg), which was used for treatment. FBG, PBG, HbA1c, serum lipid levels, homocysteine and leptin levels of the cases were determined before and at the end of 12-week treatment period.

At the end of 12-week treatment, FBG fell from 176±68 to 147±39 mg/dl (p<0.05), PBG from 224±56 to 182±46 mg/dl (p<0.05), and HbA1c from 8.7±2% to 7.6±1% (p<0.05), all the decreases being statistically significant. T. Chol., TG, LDL, VLDL and HDL levels increased, but the increase was not statistically significant. Hcy level fell from mean 10.3±2.6 to 5.14±2.7 µmol/L (p<0.05), while leptin level rose from mean 10.8±7 to 15.38±8 ng/ml (p<0.05). No changes were observed in total protein, albumin, AST and ALT levels.

Rosiglitasone treatment brought about significant changes in Hcy and leptin levels, besides regulating the blood sugar. ©2004, Fırat Üniversitesi, Tıp Fakültesi

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